INVESTIGATION OF ERYTHROMYCIN ADSORPTION INTO CHITOSAN AEROGEL PARTICLES FOR THE DEVELOPMENT OF MEDICAL DEVICES
Abstract
In this paper, the process of supercritical adsorption of erythromycin into chitosan-based aerogel particles was investigated. Aerogel particles with impregnated erythromycin were obtained us-ing supercritical carbon dioxide. The adsorption was carried out with varying temperatures and pro-cess times. During the study, the mass loading of impregnated erythromycin for all obtained samples were determined, X-ray phase analysis of crystalline erythromycin and all samples was performed, and erythromycin release curves were obtained. Based on the results of analytical studies, the parameters of the supercritical adsorption process were selected to achieve the required amount of impregnated antibiotic in the pores of chitosan-based aerogel particles, which have the potential to be used as local hemostatic agents.
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